DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma

Decrease in blood concentration of branched-chain amino acids, especially leucine, is known to promote liver carcinogenesis in patients with chronic liver disease, but the mechanism is unclear. We herein established hepatocellular carcinoma (HCC) cells knocked out for DEPDC5 by using the CRISPR/Cas9...

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Publicado en:Sci Rep
Main Authors: Mizuno, Yuki, Shimada, Shu, Akiyama, Yoshimitsu, Watanabe, Shuichi, Aida, Tomomi, Ogawa, Kosuke, Ono, Hiroaki, Mitsunori, Yusuke, Ban, Daisuke, Kudo, Atsushi, Arii, Shigeki, Yamaoka, Shoji, Tanabe, Minoru, Tanaka, Shinji
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758822/
https://ncbi.nlm.nih.gov/pubmed/29311600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18323-9
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