DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma

Decrease in blood concentration of branched-chain amino acids, especially leucine, is known to promote liver carcinogenesis in patients with chronic liver disease, but the mechanism is unclear. We herein established hepatocellular carcinoma (HCC) cells knocked out for DEPDC5 by using the CRISPR/Cas9...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Mizuno, Yuki, Shimada, Shu, Akiyama, Yoshimitsu, Watanabe, Shuichi, Aida, Tomomi, Ogawa, Kosuke, Ono, Hiroaki, Mitsunori, Yusuke, Ban, Daisuke, Kudo, Atsushi, Arii, Shigeki, Yamaoka, Shoji, Tanabe, Minoru, Tanaka, Shinji
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758822/
https://ncbi.nlm.nih.gov/pubmed/29311600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18323-9
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