Proteasome activity is required for the initiation of precancerous pancreatic lesions

Proteasome activity is significantly increased in advanced cancers, but its role in cancer initiation is not clear, due to difficulties in monitoring this process in vivo. We established a line of transgenic mice that carried the ZsGreen-degron(ODC) (Gdeg) proteasome reporter to monitor the proteaso...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Sci Rep
Κύριοι συγγραφείς: Furuyama, Takaki, Tanaka, Shinji, Shimada, Shu, Akiyama, Yoshimitsu, Matsumura, Satoshi, Mitsunori, Yusuke, Aihara, Arihiro, Ban, Daisuke, Ochiai, Takanori, Kudo, Atsushi, Fukamachi, Hiroshi, Arii, Shigeki, Kawaguchi, Yoshiya, Tanabe, Minoru
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Nature Publishing Group 2016
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886684/
https://ncbi.nlm.nih.gov/pubmed/27244456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27044
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