Proteasome activity is required for the initiation of precancerous pancreatic lesions

Proteasome activity is significantly increased in advanced cancers, but its role in cancer initiation is not clear, due to difficulties in monitoring this process in vivo. We established a line of transgenic mice that carried the ZsGreen-degron(ODC) (Gdeg) proteasome reporter to monitor the proteaso...

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Udgivet i:Sci Rep
Main Authors: Furuyama, Takaki, Tanaka, Shinji, Shimada, Shu, Akiyama, Yoshimitsu, Matsumura, Satoshi, Mitsunori, Yusuke, Aihara, Arihiro, Ban, Daisuke, Ochiai, Takanori, Kudo, Atsushi, Fukamachi, Hiroshi, Arii, Shigeki, Kawaguchi, Yoshiya, Tanabe, Minoru
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886684/
https://ncbi.nlm.nih.gov/pubmed/27244456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27044
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