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A designed DNA binding motif that recognizes extended sites and spans two adjacent major grooves
We report the rational design of a DNA-binding peptide construct composed of the DNA-contacting regions of two transcription factors (GCN4 and GAGA) linked through an AT-hook DNA anchor. The resulting chimera, which represents a new, non-natural DNA binding motif, binds with high affinity and select...
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| Pubblicato in: | Chem Sci |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Royal Society of Chemistry
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4885664/ https://ncbi.nlm.nih.gov/pubmed/27252825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc00045b |
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