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p38 MAP Kinase Links CAR Activation and Inactivation in the Nucleus via Phosphorylation at Threonine 38

Nuclear receptor constitutive androstane receptor (CAR, NR1I3), which regulates hepatic drug and energy metabolisms as well as cell growth and death, is sequestered in the cytoplasm as its inactive form phosphorylated at threonine 38. CAR activators elicit dephosphorylation, and nonphosphorylated CA...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Drug Metab Dispos
मुख्य लेखकों: Hori, Takeshi, Moore, Rick, Negishi, Masahiko
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: The American Society for Pharmacology and Experimental Therapeutics 2016
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4885487/
https://ncbi.nlm.nih.gov/pubmed/27074912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.070235
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