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p38 Mitogen–Activated Protein Kinase Regulates Nuclear Receptor CAR that Activates the CYP2B6 Gene
The constitutive active/androstane receptor (CAR) regulates hepatic drug metabolism by activating genes, such as cytochrome P450, and certain transferases. p38 Mitogen–activated protein kinase (MAPK) is highly activated in human primary hepatocytes but barely in human hepatoma cell lines including H...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3657096/ https://ncbi.nlm.nih.gov/pubmed/23539296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.051623 |
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