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Nuclear Receptor CAR Specifically Activates the Two-Pore K(+) Channel Kcnk1 Gene in Male Mouse Livers, Which Attenuates Phenobarbital-Induced Hepatic Hyperplasia

KCNK1, a member of the family of two-pore K(+) ion channels, is specifically induced in the livers of male mice after phenobarbital treatment. Here, we have determined the molecular mechanism of this male-specific activation of the Kcnk1 gene and characterized KCNK1 as a phenobarbital-inducible anti...

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Bibliografiske detaljer
Main Authors: Saito, Kosuke, Moore, Rick, Negishi, Masahiko
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576010/
https://ncbi.nlm.nih.gov/pubmed/23291559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfs338
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