Phenobarbital-Responsive Nuclear Translocation of the Receptor CAR in Induction of the CYP2B Gene

The constitutively active receptor (CAR) transactivates a distal enhancer called the phenobarbital (PB)-responsive enhancer module (PBREM) found in PB-inducible CYP2B genes. CAR dramatically increases its binding to PBREM in livers of PB-treated mice. We have investigated the cellular mechanism of P...

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Bibliographic Details
Main Authors: Kawamoto, Takeshi, Sueyoshi, Tatsuya, Zelko, Igor, Moore, Rick, Washburn, Kimberly, Negishi, Masahiko
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Transcriptional Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC84602/
https://ncbi.nlm.nih.gov/pubmed/10454578
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