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p38 MAP Kinase Links CAR Activation and Inactivation in the Nucleus via Phosphorylation at Threonine 38

Nuclear receptor constitutive androstane receptor (CAR, NR1I3), which regulates hepatic drug and energy metabolisms as well as cell growth and death, is sequestered in the cytoplasm as its inactive form phosphorylated at threonine 38. CAR activators elicit dephosphorylation, and nonphosphorylated CA...

詳細記述

保存先:
書誌詳細
出版年:Drug Metab Dispos
主要な著者: Hori, Takeshi, Moore, Rick, Negishi, Masahiko
フォーマット: Artigo
言語:Inglês
出版事項: The American Society for Pharmacology and Experimental Therapeutics 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4885487/
https://ncbi.nlm.nih.gov/pubmed/27074912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.070235
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