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p38 MAP Kinase Links CAR Activation and Inactivation in the Nucleus via Phosphorylation at Threonine 38

Nuclear receptor constitutive androstane receptor (CAR, NR1I3), which regulates hepatic drug and energy metabolisms as well as cell growth and death, is sequestered in the cytoplasm as its inactive form phosphorylated at threonine 38. CAR activators elicit dephosphorylation, and nonphosphorylated CA...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Drug Metab Dispos
Main Authors: Hori, Takeshi, Moore, Rick, Negishi, Masahiko
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society for Pharmacology and Experimental Therapeutics 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4885487/
https://ncbi.nlm.nih.gov/pubmed/27074912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.070235
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