Genomic loss of EZH2 leads to epigenetic modifications and overexpression of the HOX gene clusters in myelodysplastic syndrome

The role of EZH2 in cancer is complex and may vary depending on cancer type or stage. We examined the effect of altered EZH2 levels on H3K27 methylation, HOX gene expression, and malignant phenotype in myelodysplastic syndrome (MDS) cell lines and an in vivo xenograft model. We also studied links be...

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Vydáno v:Oncotarget
Hlavní autoři: Xu, Feng, Liu, Li, Chang, Chun-Kang, He, Qi, Wu, Ling-Yun, Zhang, Zheng, Shi, Wen-Hui, Guo, Juan, Zhu, Yang, Zhao, You-Shan, Gu, Shu-Cheng, Fei, Cheng-Ming, Li, Xiao
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884980/
https://ncbi.nlm.nih.gov/pubmed/26812882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6992
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