Sonic hedgehog inhibitors prevent colitis-associated cancer via orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2 abrogation, and tumorsphere inhibition

Sonic hedgehog (SHH) signaling is essential in normal development of the gastrointestinal (GI) tract, whereas aberrantly activated SHH is implicated in GI cancers because it facilitates carcinogenesis by redirecting stem cells. Since colitis-associated cancer (CAC) is associated with inflammatory bo...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Kangwan, Napapan, Kim, Yoon-Jae, Han, Young Min, Jeong, Migyeong, Park, Jong-Min, Go, Eun-Jin, Hahm, Ki-Baik
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884946/
https://ncbi.nlm.nih.gov/pubmed/26716648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6765
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