Sonic hedgehog inhibitors prevent colitis-associated cancer via orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2 abrogation, and tumorsphere inhibition

Sonic hedgehog (SHH) signaling is essential in normal development of the gastrointestinal (GI) tract, whereas aberrantly activated SHH is implicated in GI cancers because it facilitates carcinogenesis by redirecting stem cells. Since colitis-associated cancer (CAC) is associated with inflammatory bo...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Kangwan, Napapan, Kim, Yoon-Jae, Han, Young Min, Jeong, Migyeong, Park, Jong-Min, Go, Eun-Jin, Hahm, Ki-Baik
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884946/
https://ncbi.nlm.nih.gov/pubmed/26716648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6765
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