Sonic hedgehog inhibitors prevent colitis-associated cancer via orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2 abrogation, and tumorsphere inhibition

Sonic hedgehog (SHH) signaling is essential in normal development of the gastrointestinal (GI) tract, whereas aberrantly activated SHH is implicated in GI cancers because it facilitates carcinogenesis by redirecting stem cells. Since colitis-associated cancer (CAC) is associated with inflammatory bo...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Kangwan, Napapan, Kim, Yoon-Jae, Han, Young Min, Jeong, Migyeong, Park, Jong-Min, Go, Eun-Jin, Hahm, Ki-Baik
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884946/
https://ncbi.nlm.nih.gov/pubmed/26716648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6765
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