Effectiveness and safety of poly (ADP-ribose) polymerase inhibitors in cancer therapy: A systematic review and meta-analysis

Poly (ADP-ribose) polymerase (PARP) inhibitors are a class of small-molecule drugs suppressing PARP enzymes activity, inducing the death of cells deficient in homologous recombination repair (HRR). HRR deficiency is common in tumor cells with BRCA gene mutation. Since their first clinical trial in 2...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Bao, Zhengqiang, Cao, Chao, Geng, Xinwei, Tian, Baoping, Wu, Yanping, Zhang, Chao, Chen, Zhihua, Li, Wen, Shen, Huahao, Ying, Songmin
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Clinical Review
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884943/
https://ncbi.nlm.nih.gov/pubmed/26399274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.5367
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