Effectiveness and safety of poly (ADP-ribose) polymerase inhibitors in cancer therapy: A systematic review and meta-analysis

Poly (ADP-ribose) polymerase (PARP) inhibitors are a class of small-molecule drugs suppressing PARP enzymes activity, inducing the death of cells deficient in homologous recombination repair (HRR). HRR deficiency is common in tumor cells with BRCA gene mutation. Since their first clinical trial in 2...

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Udgivet i:Oncotarget
Main Authors: Bao, Zhengqiang, Cao, Chao, Geng, Xinwei, Tian, Baoping, Wu, Yanping, Zhang, Chao, Chen, Zhihua, Li, Wen, Shen, Huahao, Ying, Songmin
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Clinical Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884943/
https://ncbi.nlm.nih.gov/pubmed/26399274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.5367
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