Prognostic potential of the MDM2 309T>G polymorphism in stage I lung adenocarcinoma

The MDM2 protein plays an important role in the regulation of cell proliferation and apoptosis via ubiquitination and proteasome‐mediated degradation of p53. The genetic polymorphism rs2279744 (c.309T>G) of the MDM2 gene is reportedly associated with susceptibility and/or prognosis in various can...

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Publicado en:Cancer Med
Autores principales: Enokida, Yasuaki, Shimizu, Kimihiro, Atsumi, Jun, Kakegawa, Seiichi, Takase, Yoshiaki, Kaira, Kyoichi, Yashima, Hideaki, Araki, Takuya, Nakazawa, Seshiru, Ohtaki, Yoichi, Nagashima, Toshiteru, Alexander, Lezhava, Usui, Kengo, Ishikawa, Toshihisa, Hayashizaki, Yoshihide, Takeyoshi, Izumi
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2016
Materias:
Clinical Cancer Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884639/
https://ncbi.nlm.nih.gov/pubmed/27228500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.750
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