Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

To compare lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SqCC) and to identify new drivers of lung carcinogenesis, we examined exome sequences and copy number profiles of 660 lung ADC and 484 lung SqCC tumor/normal pairs. Recurrent alterations in lung SqCCs were more similar to other s...

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Published in:Nat Genet
Main Authors: Campbell, Joshua D., Alexandrov, Anton, Kim, Jaegil, Wala, Jeremiah, Berger, Alice H., Pedamallu, Chandra Sekhar, Shukla, Sachet A., Guo, Guangwu, Brooks, Angela N., Murray, Bradley A., Imielinski, Marcin, Hu, Xin, Ling, Shiyun, Akbani, Rehan, Rosenberg, Mara, Cibulskis, Carrie, Ramachandran, Aruna, Collisson, Eric A., Kwiatkowski, David J., Lawrence, Michael S., Weinstein, John N., Verhaak, Roel G. W., Wu, Catherine J., Hammerman, Peter S., Cherniack, Andrew D., Getz, Gad, Artyomov, Maxim N., Schreiber, Robert, Govindan, Ramaswamy, Meyerson, Matthew
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884143/
https://ncbi.nlm.nih.gov/pubmed/27158780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3564
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