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Ezetimibe-sensitive cholesterol uptake by NPC1L1 protein does not require endocytosis

Human NPC1L1 protein mediates cholesterol absorption in the intestine and liver and is the target of the drug ezetimibe, which is used to treat hypercholesterolemia. Previous studies concluded that NPC1L1-GFP protein trafficking is regulated by cholesterol binding and that ezetimibe blocks NPC1L1-GF...

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Xehetasun bibliografikoak
Argitaratua izan da:Mol Biol Cell
Egile Nagusiak: Johnson, Tory A., Pfeffer, Suzanne R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Cell Biology 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884074/
https://ncbi.nlm.nih.gov/pubmed/27075173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-03-0154
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