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Ezetimibe-sensitive cholesterol uptake by NPC1L1 protein does not require endocytosis
Human NPC1L1 protein mediates cholesterol absorption in the intestine and liver and is the target of the drug ezetimibe, which is used to treat hypercholesterolemia. Previous studies concluded that NPC1L1-GFP protein trafficking is regulated by cholesterol binding and that ezetimibe blocks NPC1L1-GF...
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| Published in: | Mol Biol Cell |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
The American Society for Cell Biology
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4884074/ https://ncbi.nlm.nih.gov/pubmed/27075173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-03-0154 |
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