An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells

Multiple formins regulate microtubule (MT) arrays, but whether they function individually or in a common pathway is unknown. Lysophosphatidic acid (LPA) stimulates the formation of stabilized detyrosinated MTs (Glu MTs) in NIH3T3 fibroblasts through RhoA and the formin mDia1. Here we show that anoth...

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Veröffentlicht in:Mol Biol Cell
Hauptverfasser: Bartolini, Francesca, Andres-Delgado, Laura, Qu, Xiaoyi, Nik, Sara, Ramalingam, Nagendran, Kremer, Lenor, Alonso, Miguel A., Gundersen, Gregg G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2016
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884070/
https://ncbi.nlm.nih.gov/pubmed/27030671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-07-0489
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