Загрузка...
Staufen1 impairs stress granule formation in skeletal muscle cells from myotonic dystrophy type 1 patients
Myotonic dystrophy (DM1) is caused by an expansion of CUG repeats (CUG(exp)) in the DMPK mRNA 3′UTR. CUG(exp)-containing mRNAs become toxic to cells by misregulating RNA-binding proteins. Here we investigated the consequence of this RNA toxicity on the cellular stress response. We report that cell s...
Сохранить в:
| Опубликовано в: : | Mol Biol Cell |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The American Society for Cell Biology
2016
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4884064/ https://ncbi.nlm.nih.gov/pubmed/27030674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-06-0356 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|