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Staufen1 impairs stress granule formation in skeletal muscle cells from myotonic dystrophy type 1 patients
Myotonic dystrophy (DM1) is caused by an expansion of CUG repeats (CUG(exp)) in the DMPK mRNA 3′UTR. CUG(exp)-containing mRNAs become toxic to cells by misregulating RNA-binding proteins. Here we investigated the consequence of this RNA toxicity on the cellular stress response. We report that cell s...
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| Pubblicato in: | Mol Biol Cell |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The American Society for Cell Biology
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4884064/ https://ncbi.nlm.nih.gov/pubmed/27030674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-06-0356 |
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