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Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes

[Image: see text] The development of small molecule activity-based probes (ABPs) is an evolving and powerful area of chemistry. There is a major need for synthetically accessible and specific ABPs to advance our understanding of enzymes in health and disease. α-Glucosidases are involved in diverse p...

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Dettagli Bibliografici
Pubblicato in:ACS Cent Sci
Autori principali: Jiang, Jianbing, Kuo, Chi-Lin, Wu, Liang, Franke, Christian, Kallemeijn, Wouter W., Florea, Bogdan I., van Meel, Eline, van der Marel, Gijsbert A., Codée, Jeroen D. C., Boot, Rolf G., Davies, Gideon J., Overkleeft, Herman S., Aerts, Johannes M. F. G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2016
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882745/
https://ncbi.nlm.nih.gov/pubmed/27280170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.6b00057
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