Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes

[Image: see text] The development of small molecule activity-based probes (ABPs) is an evolving and powerful area of chemistry. There is a major need for synthetically accessible and specific ABPs to advance our understanding of enzymes in health and disease. α-Glucosidases are involved in diverse p...

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Detalhes bibliográficos
Publicado no:ACS Cent Sci
Main Authors: Jiang, Jianbing, Kuo, Chi-Lin, Wu, Liang, Franke, Christian, Kallemeijn, Wouter W., Florea, Bogdan I., van Meel, Eline, van der Marel, Gijsbert A., Codée, Jeroen D. C., Boot, Rolf G., Davies, Gideon J., Overkleeft, Herman S., Aerts, Johannes M. F. G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882745/
https://ncbi.nlm.nih.gov/pubmed/27280170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.6b00057
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