Effect of trastuzumab interchain disulfide bond cleavage on Fcγ receptor binding and antibody-dependent tumour cell phagocytosis

The Fc domain of human IgG1 binds to Fcγ receptors (FcγRs) to induce effector functions such as phagocytosis. There are four interchain disulfide bonds between the H and L chains. In this study, the disulfide bonds within the IgG1 trastuzumab (TRA), which is specific for HER2, were cleaved by mild S...

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Bibliographic Details
Published in:J Biochem
Main Authors: Suzuki, Mami, Yamanoi, Ayaka, Machino, Yusuke, Ootsubo, Michiko, Izawa, Ken-ichi, Kohroki, Junya, Masuho, Yasuhiko
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
Subjects:
Regular Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882641/
https://ncbi.nlm.nih.gov/pubmed/26254483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jb/mvv074
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