AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo

Neurofibrillary tangles (NFTs) are the pathological hallmark of neurodegenerative diseases commonly known as tauopathies. NFTs result from the intracellular aggregation of abnormally and hyperphosphorylated tau proteins. Tau functions, which include the regulation of microtubules dynamics, are depen...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Domise, Manon, Didier, Sébastien, Marinangeli, Claudia, Zhao, Haitian, Chandakkar, Pallavi, Buée, Luc, Viollet, Benoit, Davies, Peter, Marambaud, Philippe, Vingtdeux, Valérie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882625/
https://ncbi.nlm.nih.gov/pubmed/27230293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26758
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