AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo

Neurofibrillary tangles (NFTs) are the pathological hallmark of neurodegenerative diseases commonly known as tauopathies. NFTs result from the intracellular aggregation of abnormally and hyperphosphorylated tau proteins. Tau functions, which include the regulation of microtubules dynamics, are depen...

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Udgivet i:Sci Rep
Main Authors: Domise, Manon, Didier, Sébastien, Marinangeli, Claudia, Zhao, Haitian, Chandakkar, Pallavi, Buée, Luc, Viollet, Benoit, Davies, Peter, Marambaud, Philippe, Vingtdeux, Valérie
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882625/
https://ncbi.nlm.nih.gov/pubmed/27230293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26758
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