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Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel Na(V)1.8
The μO-conotoxins MrVIA, MrVIB, and MfVIA inhibit the voltage-gated sodium channel Na(V)1.8, a well described target for the treatment of pain; however, little is known about the residues or structural elements that define this activity. In this study, we determined the three-dimensional structure o...
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| Опубликовано в: : | J Biol Chem |
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| Главные авторы: | , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4882450/ https://ncbi.nlm.nih.gov/pubmed/27026701 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.721662 |
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