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P-selectin expressed by a human SELP transgene is atherogenic in apolipoprotein E-deficient mice
OBJECTIVE: During inflammation, P-selectin expressed on activated endothelial cells and platelets mediates rolling adhesion of leukocytes. Atherosclerosis-prone mice crossed with P-selectin-deficient (Selp(−/−)) mice develop smaller lesions. Cytokines such as tumor necrosis factor-α increase Selp tr...
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| Pubblicato in: | Arterioscler Thromb Vasc Biol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4882243/ https://ncbi.nlm.nih.gov/pubmed/27102967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.307437 |
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