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Design, Synthesis and Biological Evaluations of Hydroxypyridone Carboxylic Acids as Inhibitors of HIV Reverse Transcriptase-Associated RNase H

Targeting the clinically unvalidated reverse transcriptase (RT) associated ribonuclease H (RNase H) for human immunodeficiency virus (HIV) drug discovery generally entails chemotypes capable of chelating two divalent metal ions in the RNase H active site. The hydroxypyridone carboxylic acid scaffold...

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Bibliografiske detaljer
Udgivet i:J Med Chem
Main Authors: Kankanala, Jayakanth, Kirby, Karen A., Liu, Feng, Miller, Lena, Nagy, Eva, Wilson, Daniel J., Parniak, Michael A., Sarafianos, Stefan G., Wang, Zhengqiang
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882222/
https://ncbi.nlm.nih.gov/pubmed/27094954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00465
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