Translation from the 5′ untranslated region shapes the integrated stress response

Translated regions distinct from annotated coding sequences have emerged as essential elements of the proteome. This includes upstream open reading frames (uORFs) present in mRNAs controlled by the integrated stress response (ISR) that show “privileged” translation despite inhibited eukaryotic initi...

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Détails bibliographiques
Publié dans:Science
Auteurs principaux: Starck, Shelley R., Tsai, Jordan C., Chen, Keling, Shodiya, Michael, Wang, Lei, Yahiro, Kinnosuke, Martins-Green, Manuela, Shastri, Nilabh, Walter, Peter
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882168/
https://ncbi.nlm.nih.gov/pubmed/26823435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad3867
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