Upregulation of Cyclooxygenase-2/Prostaglandin E(2) (COX-2/PGE(2)) Pathway Member Multiple Drug Resistance-Associated Protein 4 (MRP4) and Downregulation of Prostaglandin Transporter (PGT) and 15-Prostaglandin Dehydrogenase (15-PGDH) in Triple-Negative Breast Cancer

Elevated levels of cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)) are indicators of a poor prognosis in breast cancer. Using several independent publicly available breast cancer gene expression databases, we investigated other members of the PGE(2) pathway. PGE(2) is produced by COX-2 and...

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Bibliographic Details
Published in:Breast Cancer (Auckl)
Main Authors: Kochel, Tyler J., Goloubeva, Olga G., Fulton, Amy M.
Format: Artigo
Language:Inglês
Published: Libertas Academica 2016
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881873/
https://ncbi.nlm.nih.gov/pubmed/27257388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4137/BCBCR.S38529
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