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Involvement of PGE2 and PGDH but not COX-2 in thrombin-induced cortical neuron apoptosis
The pathways that contribute to thrombin-induced neuron death have been incompletely defined. Induction of cyclooxygenase 2 (COX-2), the enzyme that catalyzes the first step in prostaglandin synthesis, promotes neuronal injury. PGE2, a downstream product of COX-2 metabolism, is neurotoxic in vitro a...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2727552/ https://ncbi.nlm.nih.gov/pubmed/19383433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2009.01.045 |
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