Inhibiting Notch Activity in Breast Cancer Stem Cells by Glucose Functionalized Nanoparticles Carrying γ-secretase Inhibitors

Cancer stem cells (CSCs) are a challenge in cancer treatment due to their therapy resistance. We demonstrated that enhanced Notch signaling in breast cancer promotes self-renewal of CSCs that display high glycolytic activity and aggressive hormone-independent tumor growth in vivo. We took advantage...

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Vydáno v:Mol Ther
Hlavní autoři: Mamaeva, Veronika, Niemi, Rasmus, Beck, Michaela, Özliseli, Ezgi, Desai, Diti, Landor, Sebastian, Gronroos, Tove, Kronqvist, Pauliina, Pettersen, Ina K N, McCormack, Emmet, Rosenholm, Jessica M, Linden, Mika, Sahlgren, Cecilia
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881775/
https://ncbi.nlm.nih.gov/pubmed/26916284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.42
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