Cellular Protection of SNAP-25 against Botulinum Neurotoxin/A: Inhibition of Thioredoxin Reductase through a Suicide Substrate Mechanism

Botulium neurotoxins (BoNTs) are among the most lethal toxins known to man. They are comprised of seven serotypes with BoNT/A being the most deadly; yet, there is no approved therapeutic for their intoxication or one that has even advanced to clinical trials. Botulinum neurotoxicity is ultimately go...

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Bibliografiska uppgifter
I publikationen:J Am Chem Soc
Huvudupphovsmän: Seki, Hajime, Xue, Song, Pellett, Sabine, Šilhár, Peter, Johnson, Eric A., Janda, Kim D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881748/
https://ncbi.nlm.nih.gov/pubmed/27070533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b12929
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