Pooled Analysis of the Prognostic and Predictive Effects of KRAS Mutation Status and KRAS Mutation Subtype in Early-Stage Resected Non–Small-Cell Lung Cancer in Four Trials of Adjuvant Chemotherapy

PURPOSE: We undertook this analysis of KRAS mutation in four trials of adjuvant chemotherapy (ACT) versus observation (OBS) to clarify the prognostic/predictive roles of KRAS in non–small-cell lung cancer (NSCLC). METHODS: KRAS mutation was determined in blinded fashion. Exploratory analyses were pe...

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Publicat a:J Clin Oncol
Autors principals: Shepherd, Frances A., Domerg, Caroline, Hainaut, Pierre, Jänne, Pasi A., Pignon, Jean-Pierre, Graziano, Stephen, Douillard, Jean-Yves, Brambilla, Elizabeth, Le Chevalier, Thierry, Seymour, Lesley, Bourredjem, Abderrahmane, Teuff, Gwénaël Le, Pirker, Robert, Filipits, Martin, Rosell, Rafael, Kratzke, Robert, Bandarchi, Bizhan, Ma, Xiaoli, Capelletti, Marzia, Soria, Jean-Charles, Tsao, Ming-Sound
Format: Artigo
Idioma:Inglês
Publicat: American Society of Clinical Oncology 2013
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ORIGINAL REPORTS
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881333/
https://ncbi.nlm.nih.gov/pubmed/23630215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2012.48.1390
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