Pooled Analysis of the Prognostic and Predictive Effects of TP53 Comutation Status Combined With KRAS or EGFR Mutation in Early-Stage Resected Non–Small-Cell Lung Cancer in Four Trials of Adjuvant Chemotherapy

PURPOSE: Our previous work evaluated individual prognostic and predictive roles of TP53, KRAS, and EGFR in non–small-cell lung cancer (NSCLC). In this analysis, we explore the prognostic and predictive roles of TP53/KRAS and TP53/EGFR comutations in randomized trials of adjuvant chemotherapy versus...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Shepherd, Frances A., Lacas, Benjamin, Le Teuff, Gwénaël, Hainaut, Pierre, Jänne, Pasi A., Pignon, Jean-Pierre, Le Chevalier, Thierry, Seymour, Lesley, Douillard, Jean-Yves, Graziano, Stephen, Brambilla, Elizabeth, Pirker, Robert, Filipits, Martin, Kratzke, Robert, Soria, Jean-Charles, Tsao, Ming-Sound
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2017
Assuntos:
ORIGINAL REPORTS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6075828/
https://ncbi.nlm.nih.gov/pubmed/28453411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2016.71.2893
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