Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIV

BACKGROUND: Many HIV infected individuals with suppressed viral loads experience chronic immune activation frequently developing neurological impairment designated as HIV associated neurocognitive disorder (HAND). Adjunctive therapies may reduce HIV associated inflammation and therefore decrease the...

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Bibliographic Details
Published in:	J Transl Med
Main Authors:	Barrett, Jeffrey S., Spitsin, Sergei, Moorthy, Ganesh, Barrett, Kyle, Baker, Kate, Lackner, Andrew, Tulic, Florin, Winters, Angela, Evans, Dwight L., Douglas, Steven D.
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2016
Subjects:	Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4880976/ https://ncbi.nlm.nih.gov/pubmed/27230663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0904-y
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Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIV

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