Platinum-Based Drugs and DNA Interactions Studied by Single-Molecule and Bulk Measurements

Platinum-containing molecules are widely used as anticancer drugs. These molecules exert cytotoxic effects by binding to DNA through various mechanisms. The binding between DNA and platinum-based drugs hinders the opening of DNA, and therefore, DNA duplication and transcription are severely hampered...

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Bibliographische Detailangaben
Veröffentlicht in:Biophys J
Hauptverfasser: Salerno, Domenico, Beretta, Giovanni L., Zanchetta, Giuliano, Brioschi, Simone, Cristofalo, Matteo, Missana, Natalia, Nardo, Luca, Cassina, Valeria, Tempestini, Alessia, Giovannoni, Roberto, Cerrito, Maria Grazia, Zaffaroni, Nadia, Bellini, Tommaso, Mantegazza, Francesco
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2016
Schlagworte:
Nucleic Acids and Genome Biophysics Proteins
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880801/
https://ncbi.nlm.nih.gov/pubmed/27224480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.02.030
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