Nanomechanics of Diaminopurine-Substituted DNA

2,6-diaminopurine (DAP) is a nucleobase analog of adenine. When incorporated into double-stranded DNA (dsDNA), it forms three hydrogen bonds with thymine. Rare in nature, DAP substitution alters the physical characteristics of a DNA molecule without sacrificing sequence specificity. Here, we show th...

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Bibliographic Details
Published in:Biophys J
Main Authors: Cristofalo, Matteo, Kovari, Daniel, Corti, Roberta, Salerno, Domenico, Cassina, Valeria, Dunlap, David, Mantegazza, Francesco
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6403411/
https://ncbi.nlm.nih.gov/pubmed/30795872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.01.027
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