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miR-190 Enhances HIF-Dependent Responses to Hypoxia in Drosophila by Inhibiting the Prolyl-4-hydroxylase Fatiga

Cellular and systemic responses to low oxygen levels are principally mediated by Hypoxia Inducible Factors (HIFs), a family of evolutionary conserved heterodimeric transcription factors, whose alpha- and beta-subunits belong to the bHLH-PAS family. In normoxia, HIFα is hydroxylated by specific proly...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: De Lella Ezcurra, Ana Laura, Bertolin, Agustina Paola, Kim, Kevin, Katz, Maximiliano Javier, Gándara, Lautaro, Misra, Tvisha, Luschnig, Stefan, Perrimon, Norbert, Melani, Mariana, Wappner, Pablo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880290/
https://ncbi.nlm.nih.gov/pubmed/27223464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006073
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