The Cystathionine-β-synthase Domains on the Guanosine 5′-Monophosphate Reductase and Inosine 5′-Monophosphate Dehydrogenase Enzymes from Leishmania Regulate Enzymatic Activity in Response to Guanylate and Adenylate Nucleotide Levels

The Leishmania guanosine 5′-monophosphate reductase (GMPR) and inosine 5′-monophosphate dehydrogenase (IMPDH) are purine metabolic enzymes that function maintaining the cellular adenylate and guanylate nucleotide. Interestingly, both enzymes contain a cystathionine-β-synthase domain (CBS). To invest...

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Publicado en:Mol Microbiol
Main Authors: Smith, Sabrina, Boitz, Jan, Chidambaram, Ehzilan Subramanian, Chatterjee, Abhishek, Ait-Tihyaty, Maria, Ullman, Buddy, Jardim, Armando
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879609/
https://ncbi.nlm.nih.gov/pubmed/26853689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.13352
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