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Inosine 5′-monophosphate dehydrogenase of Escherichia coli K12: the nature of the inhibition by guanosine 5′-monophosphate (Short Communication)

When IMP is the variable substrate, IMP dehydrogenase (EC 1.2.1.14) gives non-linear Lineweaver–Burk plots in the presence of GMP. At 0.1mm-GMP the Hill coefficient n=1.15 and at 0.2mm-GMP n=1.34. In the absence of GMP n=1.0. The fact that n exceeds 1.0 in the presence of GMP indicates that the enzy...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lambden, Paul R., Drabble, William T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1973
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1177741/
https://ncbi.nlm.nih.gov/pubmed/4354743
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