Simulation and Prediction of the Drug‐Drug Interaction Potential of Naloxegol by Physiologically Based Pharmacokinetic Modeling

Naloxegol, a peripherally acting μ‐opioid receptor antagonist for the treatment of opioid‐induced constipation, is a substrate for cytochrome P450 (CYP) 3A4/3A5 and the P‐glycoprotein (P‐gp) transporter. By integrating in silico, preclinical, and clinical pharmacokinetic (PK) findings, minimal and f...

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Vydáno v:CPT Pharmacometrics Syst Pharmacol
Hlavní autoři: Zhou, D, Bui, K, Sostek, M, Al‐Huniti, N
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879473/
https://ncbi.nlm.nih.gov/pubmed/27299937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12070
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