Prediction of Drug–Drug Interactions Between Opioids and Overdosed Benzodiazepines Using Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation

BACKGROUND: Researchers have long been interested in the potential drug–drug interactions (DDIs) between opioids and benzodiazepines. However, much remains unknown concerning the interactions between these two drug classes. The objective of this work is to study the mechanism underlying the DDIs bet...

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Veröffentlicht in:Drugs R D
Hauptverfasser: Ji, Beihong, Liu, Shuhan, Xue, Ying, He, Xibing, Man, Viet Hoang, Xie, Xiang-Qun, Wang, Junmei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2019
Schlagworte:
Original Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6738369/
https://ncbi.nlm.nih.gov/pubmed/31482303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40268-019-00282-3
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