Inhibitors of Ribosome Rescue Arrest Growth of Francisella tularensis at All Stages of Intracellular Replication

Bacteria require at least one pathway to rescue ribosomes stalled at the ends of mRNAs. The primary pathway for ribosome rescue is trans-translation, which is conserved in >99% of sequenced bacterial genomes. Some species also have backup systems, such as ArfA or ArfB, which can rescue ribosomes...

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Bibliografiska uppgifter
I publikationen:Antimicrob Agents Chemother
Huvudupphovsmän: Goralski, Tyler D. P., Dewan, Kalyan K., Alumasa, John N., Avanzato, Victoria, Place, David E., Markley, Rachel L., Katkere, Bhuvana, Rabadi, Seham M., Bakshi, Chandra Shekhar, Keiler, Kenneth C., Kirimanjeswara, Girish S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2016
Ämnen:
Experimental Therapeutics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879415/
https://ncbi.nlm.nih.gov/pubmed/26953190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03089-15
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