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Ectodomain cleavage of FLT1 regulates receptor activation and function and is not required for its downstream intracellular cleavage
Flt1 is a cell surface VEGF receptor which is cleaved to release an N-terminal ectodomain which binds VEGF and PlGF and can antagonize the effects of VEGF in the extracellular milieu. To further evaluate Flt1 processing we expressed tagged Flt1 constructs in HEK293 and COS7 cells where we demonstrat...
Gespeichert in:
| Veröffentlicht in: | Exp Cell Res |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4879079/ https://ncbi.nlm.nih.gov/pubmed/27017929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2016.03.020 |
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