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Mutations of FLT3 receptor affect its surface glycosylation, intracellular localization, and downstream signaling

This review describes the effects of FLT3 mutations that alter its intracellular localization and modify its glycosylation, leading to differences in downstream signaling pathways. The most common type of FLT3 mutation, internal tandem duplication (FLT3-ITD), leads to localization in the endoplasmic...

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Detalhes bibliográficos
Publicado no:Leuk Res Rep
Autor principal: Takahashi, Shinichiro
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911968/
https://ncbi.nlm.nih.gov/pubmed/31853441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lrr.2019.100187
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