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Down-regulation of hTERT and Cyclin D1 Transcription via PI3K/Akt and TGF-β Pathways in MCF-7 Cancer Cells with PX-866 and Raloxifene

Human telomerase reverse transcriptase (hTERT) is the catalytic and limiting component of telomerase and also a transcription factor. It is critical to the integrity of the ends of linear chromosomes and to the regulation, extent and rate of cell cycle progression in multicellular eukaryotes. The le...

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Detalhes bibliográficos
Publicado no:Exp Cell Res
Main Authors: Peek, Gregory W., Tollefsbol, Trygve O.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879042/
https://ncbi.nlm.nih.gov/pubmed/27017931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2016.03.022
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