A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder

In 1994 in the Journal of Cell Science, Hennekes and Nigg reported that changing valine to arginine at the endoproteolytic cleavage site in chicken prelamin A abolishes its conversion to lamin A. The consequences of this mutation in an organism have remained unknown. We now report that the correspon...

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Dades bibliogràfiques
Publicat a:J Cell Sci
Autors principals: Wang, Yuexia, Lichter-Konecki, Uta, Anyane-Yeboa, Kwame, Shaw, Jessica E., Lu, Jonathan T., Östlund, Cecilia, Shin, Ji-Yeon, Clark, Lorraine N., Gundersen, Gregg G., Nagy, Peter L., Worman, Howard J.
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists Ltd 2016
Matèries:
Short Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878994/
https://ncbi.nlm.nih.gov/pubmed/27034136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.187302
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