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Mechanical signals regulate and activate SNAIL1 protein to control the fibrogenic response of cancer-associated fibroblasts

Increased deposition of collagen in extracellular matrix (ECM) leads to increased tissue stiffness and occurs in breast tumors. When present, this increases tumor invasion and metastasis. Precisely how this deposition is regulated and maintained in tumors is unclear. Much has been learnt about mecha...

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Bibliografiske detaljer
Udgivet i:J Cell Sci
Main Authors: Zhang, Kun, Grither, Whitney R., Van Hove, Samantha, Biswas, Hirak, Ponik, Suzanne M., Eliceiri, Kevin W., Keely, Patricia J., Longmore, Gregory D.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878991/
https://ncbi.nlm.nih.gov/pubmed/27076520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.180539
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